The Petes are entrusted with the key to the house while Mom and Dad go away on a trip for two days. Just when it looks like their plan to stage the ultimate bicycle race around the house (The Wrigley 500) is about to materialize, Big Pete is struck by hormones and instead chooses to vie for the attention of his latest sweet-heart, Margie Corsall. Little Pete sells the house in retaliation to the nicest family ever, the Krechmars. Big Pete tries to set things right with his brother and they attempt to regain ownership of the house before Mom and Dad return.

Big Pete offers to let his friend Teddy stay over while his parents are away and begins to notice just how many annoying habits Teddy has. Meanwhile, Little Pete tries to get in touch with the land.

Little Pete's lucky penny runs out of luck one day, so he, Nona, Monica, and Wayne set out on a journey to recharge it by letting the Midnight Express run over it. Pit Stain, Little Pete's arch nemesis, and his henchmen (Hair Net & Drawstring) catches on and tails them, and Pete is forced to battle Pit Stain without the power of his lucky penny. Parody of Stand By Me.

Big Pete tries to obtain the coveted position of Senior Lifeguard while Little Pete fights to abolish the hated Adult Swim. Big Pete is forced to choose between the power of the lifeguard chair and his friendship with his brother.

Little Pete attends his first school dance and Big Pete develops a crush on the lead singer of the hired band (Luscious Jackson). Pit Stain learns of Little Pete's fear of dancing and tries to exploit it, and Nona tries to avoid the embarrassment of dancing with her "Pop," (Iggy Pop) who takes the stage and sings a song for her.

Spring fever hits Wellsville hard and everyone begins dropping like flies. Big Pete is smitten by a star member of the tennis team, Ellen realizes her true feelings for him, and Pit Stain is head over heals for Nona. Little Pete falls for Eunice Puell, the mail lady, despite his most sincere efforts to avoid love through his mantra, "Love bites." Nona is the last to go, finally falling for Little Pete. The results of this immense love web build toward a climax.

It's April 1st and little Pete has planned the best April Fool's joke ever. With the help of Nona, Monica the KrebScout, Wayne, and surprisingly, Pit Stain and his cronies, he pulls off the mother of all pranks. The butt of his joke? Principal Swinger and a group of eight singers that come to the school annually to promote hygiene.

Little Pete, Monica, and Wayne get trapped in the school after it closes and are stuck for the night. They attempt to elude a fearsome school legend, who they are eventually forced to confront.

Big Pete and his friends reach the age of responsibility and take Driver's Ed from Mr. Slurm, the shop teacher.

Big Pete tries to get a varsity letter and climb to the top of the social ladder the easy way by joining the wrestling team, and finds that individual sports are not a cakewalk. He trains for a confrontation at the big match with "Endless" Mike Hellstrom, and is coached by Ellen, a huge wrestling fan. However, Ellen's efforts to coach Big Pete are threatened by the school's wrestling coach, Beano Glattner.

Little Pete prolongs Christmas for as long as possible after the holiday's end, in an attempt to keep the neighborhood in a constant aura of yuletide joy. His efforts are threatened by a bitter garbage man who enjoys destroying Christmas trees and the holiday spirit they represent.

Big Pete chooses to become schoolbus driver Stu Benedict's apprentice for the week to be near Penelope Ghiruto, while Ellen stocks vending machines.

The gang spends a typical Saturday in Wellsville. Ellen tries to deliver a pizza dressed as a bunny, Wayne tries to keep his new white sneakers clean, Monica keeps the streets safe as she looks for an evil ninja, Big Pete gets a haircut, and Bus Driver Stu gets frustrated with a traffic light that rarely changes to green, and when it does, won't stay that way for more than a few seconds.