Sam and his brew team at Dogfish Head collaborate with Sony Records to create a new fusion beer in honor of the 40th Anniversary of the classic Miles Davis' album, "Bitches Brew." With a very tight deadline, they must formulate, tweak, produce and ship 50,000 bottles of custom beer.

Sam heads to Peru to explore an ancient corn based brew called Chicha. Since he's always looking for authentic brews, Sam decides it's worth following the ancient recipe -- including chewing up the corn to naturally speed fermentation. So it's all hands on deck in Delaware when the Dogfish staff is enlisted to use their own saliva to brew their newest craft beer.

Sam travels to New Zealand to make an indigenous brew for Beervana, the annual craft-brewing competition. Meanwhile, at the Milton brewery, fears of dumping a significant amount of Punkin Ale loom when it ends up in the wrong type of glass bottles.

When a company approaches Sam about making a beer out of cedar scraps salvaged from their hand-made surfboards, Dogfish jumps at the chance to create their first "cedar-fied" beer. But, the team faces a major setback when 9,000 gallons of their signature beer, 120 Minute IPA, gets flagged by Quality Control.

Dogfish Head is about to brew a batch of "Chateau Jihau", a 9000 year-old recipe based on pottery jars recovered from a village in Northern China. Sam heads to Egypt in order to bring back to life beer from one of man's earliest civilizations.

Italian craft breweries are examined. Dogfish Head Brewery opens its newest restaurant: a rooftop brewpub in New York City's Eataly, and creates a series of specialty beers for the pub.