Based on the 2000 book of the same name by Emmanuel Carrère, it is inspired by the real-life story of Jean-Claude Romand. L'Adversaire's protagonist Jean-Marc Faure (Auteuil) pursues an imaginary career as a doctor of medicine in a plot more closely based on Romand's life and Carrère's book than was Laurent Cantet's 2001 film L'Emploi du Temps. The film was nominated for a Palme d'Or at the 2002 Cannes Film Festival.

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